K145 hydrochloride
CAS No. 1449240-68-9
K145 hydrochloride ( —— )
Catalog No. M29603 CAS No. 1449240-68-9
K145 hydrochloride is a selective sphk2 inhibitor with substrate competitiveness and oral activity, with IC50 of 4.3 μM and Ki of 6.4 μM. K145 hydrochloride can induce apoptosis and has strong antitumor activity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 45 | In Stock |
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10MG | 61 | In Stock |
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25MG | 87 | In Stock |
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50MG | 122 | In Stock |
|
100MG | Get Quote | In Stock |
|
200MG | Get Quote | In Stock |
|
500MG | Get Quote | In Stock |
|
1G | Get Quote | In Stock |
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Biological Information
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Product NameK145 hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionK145 hydrochloride is a selective sphk2 inhibitor with substrate competitiveness and oral activity, with IC50 of 4.3 μM and Ki of 6.4 μM. K145 hydrochloride can induce apoptosis and has strong antitumor activity.
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DescriptionK145 hydrochloride is a selective sphk2 inhibitor with substrate competitiveness and oral activity, with IC50 of 4.3 μM and Ki of 6.4 μM. K145 hydrochloride can induce apoptosis and has strong antitumor activity.(In Vitro):K145 hydrochloride inhibited the activity of SphK2 in a dose-dependent manner with an IC50 of 4.30 μM. The Lineweaver-Burk analysis revealed a Ki of 6.4±0.7 μM for SphK2 and indicated that K145 hydrochloride is a substrate competitive inhibitor (with sphingosine). K145 hydrochloride accumulates in U937 cells, suppresses the S1P level, and inhibits SphK2. K145 hydrochloride also exhibited inhibitory effects on the growth of U937 cells as well as apoptotic effects in U937 cells, and that these effects may be through the inhibition of downstream ERK and Akt signaling pathways.(In Vivo):In BALB/c-nu mice injected with U937 cells, K145 hydrochloride (50 mg/kg; oral gavage; for 15 days) treatment significantly inhibited the growth of U937 tumors at 50 mg/kg dose and no apparent toxicity was observed.
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Synonyms——
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PathwayApoptosis
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TargetApoptosis
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RecptorApoptosis
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Research Area——
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Indication——
Chemical Information
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CAS Number1449240-68-9
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Formula Weight384.9
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Molecular FormulaC18H25ClN2O3S
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Purity>98% (HPLC)
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Solubility——
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SMILESCl.CCCCOc1ccc(CC\C=C2/SC(=O)N(CCN)C2=O)cc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
molnova catalog
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